The Revolution of CAR-NK Therapy: Transforming Disease Treatment
The Revolution of CAR-NK Therapy: Transforming Disease Treatment
In the ever-evolving landscape of medical innovation, one breakthrough stands out—a transformative approach known as CAR-NK therapy. This groundbreaking development has the potential to revolutionize disease treatment, offering a safer and more effective solution for patients. Join us as we delve into the five pivotal aspects of CAR-NK therapy, reshaping the future of medical care.
CAR-NK Therapy: Why is it a Game-Changer in Disease Treatment
1. Enhanced Safety and Versatility:
At its core, CAR-NK therapy represents a monumental shift in the treatment of various medical conditions. What sets it apart is its enhanced safety and versatility. Unlike its predecessor, CAR-T therapy, which uses the patient’s own T cells, CAR-NK cells can be derived from healthy donors or stem cells. This distinction significantly reduces the risk of complications, including graft-versus-host disease and cytokine release syndrome, which can sometimes accompany CAR-T therapy. Moreover, CAR-NK cells can be stored and used off-the-shelf, making them more readily available for patients in need.
2. Effective Against a Wide Range of Diseases:
The versatility of CAR-NK therapy extends to its effectiveness against a diverse spectrum of diseases. These remarkable cells possess the ability to target multiple antigens present on various cell types. From hematologic conditions to solid tumors, CAR-NK therapy demonstrates remarkable efficacy. Furthermore, it has the potential to counteract the mechanisms employed by cells to evade the immune system, such as immunosuppression and antigen loss.
3. Cost-Efficiency and Speedy Production:
Another compelling aspect of CAR-NK therapy is its cost-efficiency and rapid production. In comparison to the complex and personalized approach required for CAR-T therapy, CAR-NK cells can be manufactured on a larger scale. This streamlined production process significantly lowers costs, making this innovative therapy more accessible to a wider range of patients. The affordability of CAR-NK therapy brings us one step closer to a future where cutting-edge treatments are within reach for all.
4. A Thriving Field with Promising Potential:
While CAR-NK therapy is still in its early stages of clinical development, the initial results are promising and encouraging. Researchers and medical professionals worldwide are working tirelessly to unlock its full potential. Early trials have demonstrated its safety and efficacy, raising hopes for further breakthroughs in disease treatment.
CAR-NK therapy represents a monumental leap forward in disease treatment. At ISSCA.com, we are dedicated to advancing knowledge in the realm of regenerative medicine. We invite you to explore the transformative possibilities of CAR-NK therapy and its potential to reshape the future of medical care. As we journey together, you’ll discover that the horizon of possibilities in healthcare is continually expanding.
Explore our courses and international congresses at ISSCA.com to deepen your knowledge in regenerative medicine.
- Published in Blog
Beyond Boundaries: How Stem Cells Are Reshaping Organ and Tissue Transplantation
Within the sacred corridors of medical advancement, a profound transformation is silently taking place, poised to reshape the very foundations of organ and tissue transplantation. Envision a realm where donor shortages and the specter of immune system rejection fade into history, and where medical horizons stretch to unprecedented frontiers. In this immersive voyage, we embark on a journey to unmask the enigmatic power of stem cells in the realm of transplantation, a journey that invites you to witness the precipice of medical progress.
Stem Cells: Pioneers of Regeneration
Stem cells, those remarkable architects of the body’s rejuvenation, harbor an astonishing talent for metamorphosis, seamlessly transforming into diverse cell types to mend and invigorate damaged tissues. When seamlessly integrated into the landscape of organ and tissue transplantation, stem cells open a tantalizing path towards surmounting the inherent complexities of these procedures. Whether it’s breathing vitality into faltering heart muscles, reviving the compromised functionality of a beleaguered liver, or revitalizing lungs beset by adversity, stem cells emerge as the harbinger of transformation for transplantation outcomes.
The Choreography of Compatibility
Navigating the intricate choreography of compatibility between donor and recipient is one of the most formidable tasks in transplantation. The ever-watchful immune system often triggers rejection, undermining even the most meticulous transplantation endeavors. Yet, stem cells are orchestrating a symphony of change. Through ingenious techniques, researchers are tapping into stem cells’ immunomodulatory prowess, crafting an environment of harmonious coexistence between donor and recipient. This revolutionary approach not only mitigates the risks of rejection but also broadens the spectrum of viable donors.
A Symphony of Science
The harmony between stem cells and transplantation is not an untested hypothesis; it’s a symphony composed through rigorous scientific exploration. An extensive repertoire of peer-reviewed studies, gracing the pages of prestigious journals such as The Lancet and Nature Communications, underscores the potential of stem cells to elevate transplant success rates. These studies illuminate advancements spanning from refining graft survival to hastening the regeneration of vital tissues, a resounding affirmation of the transformative capabilities underpinning stem cell-driven transplantation.
Embark on a Journey of Revelation
Eager to unravel the mysteries encapsulating stem cell-powered transplantation? We extend a heartfelt invitation to embark on an illuminating expedition through our comprehensive training courses in regenerative medicine. Enrich your understanding under the tutelage of eminent experts, delving into the most recent breakthroughs, evidence-based methodologies, and clinical applications. Step into a realm where the boundaries of medical possibilities are redrawn, where your perception of transplantation is enriched, and where you assume the mantle of a pioneer in the regenerative revolution.
The fusion of stem cells and organ transplantation isn’t confined to the realm of scientific speculation; it represents a monumental stride towards re-scripting the destinies of countless lives. As we venture into an epoch where medical accomplishments redefine our limits, the expedition becomes all the more exhilarating.
Join us at issca.us, where the convergence of science and hope awaits. Immerse yourself in the vanguard of regenerative medicine, where the transformative prowess of stem cells beckons. Together, we shall forge ahead, empowered by the symphony of possibilities, shaping a brighter, healthier future for generations to come.
- Published in Blog
Exploring the Frontier of Regenerative Medicine: Unraveling Autologous and Allogeneic Stem Cells
Exploring the Frontier of Regenerative Medicine: Unraveling Autologous and Allogeneic Stem Cells
In the realm of modern medicine, a groundbreaking field has emerged, promising to reshape the way we approach healing and rejuvenation – regenerative medicine. At the heart of this revolution lie stem cells, the unsung heroes of tissue repair and regeneration. In this comprehensive exploration, we delve into the intricate differences between two crucial types of stem cells: autologous and allogeneic. Prepare to be captivated by the scientific intricacies that underpin these extraordinary cells and discover how they’re poised to redefine medical possibilities.
Autologous Stem Cells: A Personalized Touch
Imagine harnessing the power of your body’s own natural healing abilities. Autologous stem cells make this vision a reality. Derived from your own tissues – be it bone marrow, adipose tissue, or other sources – these cells hold the promise of personalized healing. The process involves harvesting the stem cells, processing them to enhance their therapeutic potential, and then reintroducing them into the body. This “self-healing” approach minimizes the risk of rejection and side effects, making autologous stem cell therapies an attractive option for many.
- Scientific Precision:
Autologous stem cell therapies are supported by a wealth of scientific evidence. Studies published in esteemed journals like the Journal of Translational Medicine and Stem Cell Research & Therapy have highlighted their potential in diverse applications, from musculoskeletal disorders to cardiovascular conditions. This approach holds immense promise for targeted healing, while minimizing the risk of immune system complications.
Allogeneic Stem Cells: A Shared Resource for Healing
In the quest for regenerative solutions, allogeneic stem cells emerge as a game-changer. These cells are sourced from carefully screened donors and subsequently administered to patients. By tapping into a shared pool of stem cells, medical practitioners can provide a standardized treatment option that’s readily available. Allogeneic stem cells hold the potential to address a broad spectrum of conditions, offering a versatile and accessible avenue for regenerative therapies.
- Scientific Validation:
The science behind allogeneic stem cell therapies is compelling. Rigorous research published in renowned journals such as the Journal of Stem Cells and Development and Stem Cells Translational Medicine has underscored their efficacy in various medical scenarios. This approach not only broadens the scope of treatment but also expedites the therapeutic process, presenting an exciting frontier in regenerative medicine.
Embrace the Future with Knowledge:
Intrigued by the dynamic interplay of autologous and allogeneic stem cells in regenerative medicine? We invite you to embark on a transformative journey of discovery through our comprehensive training courses. Our platform offers unparalleled insights into the latest advancements, evidence-based practices, and clinical applications of these remarkable stem cells. Guided by esteemed experts in the field, our courses provide a unique opportunity to stay at the forefront of regenerative medicine’s evolution.
As the horizon of medicine expands to encompass regenerative possibilities, autologous and allogeneic stem cells take center stage. These cellular protagonists hold the key to unlocking personalized healing and broad-spectrum rejuvenation, ushering in an era of medical advancement like never before. Join us in our mission to unravel the mysteries of regenerative medicine and explore the profound potential of stem cells. Visit issca.us today, and together, let’s embark on a journey that could reshape the landscape of healthcare for generations to come.
- Published in Blog
ISSCA Announces Its Next World Congress 2023: The Premier Regenerative Medicine Event of the Year
The International Society for Stem Cell Application (ISSCA) is excited to announce the much-anticipated World Congress 2023, further establishing its role as the primary global hub for regenerative medicine. The event is set to occur from November 10 to 12, 2023, at the esteemed Crowne Plaza Istanbul Florya Hotel in Istanbul, Turkey. Drawing on the remarkable achievements of the previous conference held at the Radisson Blu Hotel on September 23 to 26, 2022, ISSCA is prepared to exceed all predictions with this highly anticipated World Congress.
During the three-day congress, prominent physicians from across the globe will come together, offering an extensive agenda of presentations and interactive sessions. “Our ISSCA Congresses once more provide a great opportunity to disseminate this information to the physicians who need it most, and we plan to organize as many as we can before the end of the year,” says ISSCA Managing Director and CEO of Global Stem Cells Group Benito Novas about the upcoming congress.
Participants can anticipate captivating workshops, including those focused on aesthetic and clinical applications, aimed at delving into the most recent advancements within the rapidly evolving field of regenerative medicine.
In a full schedule of lectures, the congress will shed light on significant subjects such as molecular biology, innovative treatment approaches in surgical and cosmetic domains, and the latest cutting-edge technologies that have emerged in the field. In addition, the congress will explore the legal framework encompassing regenerative medicine practices on a global scale, acknowledging the varying degrees of involvement by various national governments.
This conference demonstrates ISSCA’s dedication to facilitating a transformative change from traditional healthcare methods to regenerative medicine while showcasing the most recent innovative discoveries and progress in all aspects of stem cell research.
The Crowne Plaza Istanbul Florya Hotel, known for its modern facilities and ideal location in Istanbul, Turkey, will serve as the prestigious venue for this highly anticipated event. Its comfortable and conducive environment provides the optimum platform for attendees to exchange ideas and establish new partnerships.
The ISSCA World Congress 2023 in Istanbul is a must-attend event for anyone interested in regenerative medicine. With a focus on innovation, collaboration, and knowledge exchange, the congress promises to be a transformative experience for all attendees. Whether you are a scientist, physician, or healthcare professional, this event offers an opportunity to gain valuable insights and forge new connections with like-minded individuals from around the world.
For more information about the November 10 to 12 ISSCA World Congress 2023, please visit our official website today.
About ISSCA:
The International Society for Stem Cell Application (ISSCA) is a multidisciplinary community of scientists and physicians who aspire to treat diseases and lessen human suffering through advances in science, technology, and the practice of regenerative medicine. ISSCA serves its members through advancements made in the specialty of regenerative medicine.
The mission of the International Stem Cell Certification Agency (ISSCA) is to establish itself as a global leader in regenerative medicine certification, education, research, and training.
ISSCA provides certification training in cities worldwide because it recognizes the importance of standards and certifications in regenerative medicine as a medical specialty. To help more people, both locally and globally, as the demand for more doctors interested in and comfortable with regenerative medicine surges. ISSCA’s mission is to advance quality and uniformity in regenerative medicine worldwide.
About Global Stem Cells Group:
The Global Stem Cell Group is a family of several companies focused on stem cell medicine and research. The company uses its network to bring leadership in regenerative medicine training, research, and patient applications.
GSCG’s mission is to allow physicians to present the benefits of stem cell medicine to patients worldwide. The company also partners with policymakers, educators, and regulators to promote regenerative medicine.
Global Stem Cells Group is a publicly traded company operating under the symbol MSSV. https://finance.yahoo.com/quote/mssv/
To learn more about Global Stem Cells Group, Inc.’s companies visit our website www.stemcellsgroup.com or call +1 305 560 5331
Safe Harbor Statement:
Statements in this news release may be “forward-looking statements”. Forward-looking statements include, but are not limited to, statements that express our intentions, beliefs, expectations, strategies, predictions, or any other information relating to our future activities or other future events or conditions. These statements are based on current expectations, estimates, and projections about our business based partly on assumptions made by management. These statements are not guarantees of future performance and involve risks, uncertainties, and assumptions that are difficult to predict. Therefore, actual outcomes and results may and are likely to differ materially from what is expressed or forecasted in forward-looking statements due to numerous factors. Any forward-looking statements speak only as of the date of this news release, and The Global Stem Cells Group undertakes no obligation to update any forward-looking statement to reflect events or circumstances after the date of this news release. This press release does not constitute a public offer of any securities for sale. Any securities offered privately will not be or have not been registered under the Act and may not be offered or sold in the United States absent registration or an applicable exemption from registration requirements.
- Published in News
Ozone Therapy: A Promising Alternative Treatment with Potential Benefits
Ozone therapy is a promising alternative medical treatment that has gained popularity in recent years. It involves the administration of ozone, a form of oxygen, to treat various medical conditions, ranging from chronic pain to infections. Although the scientific evidence on the effectiveness of ozone therapy remains limited, many people claim to have experienced significant health benefits from this alternative treat
ment. In this article, we’ll explore the potential benefits and risks of ozone therapy, as well as the latest research on this alternative medical treatment.
What is ozone therapy?
Ozone therapy is a safe, non-invasive, and effective alternative medical treatment that has been used for over a century. It involves the administration of ozone, a gas made up of three oxygen atoms, to the body in various forms, such as injections, insufflations, or topical applications. Ozone is a powerful oxidant that can damage cells and tissues, which can have positive or negative effects, depending on the form and amount of ozone used.
One of the key benefits of ozone therapy is its ability to improve blood circulation and oxygen delivery to the tissues, which can help reduce inflammation, support wound healing, and boost immune function. Additionally, ozone therapy is believed to have antimicrobial and antiviral properties, which may help fight infections caused by bacteria, viruses, and fungi.
What are the potential benefits of ozone therapy?
Ozone therapy has been used to treat a wide range of medical conditions, including:
- Chronic pain: Ozone therapy may help reduce pain and inflammation in conditions such as osteoarthritis, herniated discs, and fibromyalgia.
- Infections: Ozone therapy may help fight infections caused by bacteria, viruses, and fungi, including Lyme disease, hepatitis, and HIV.
- Autoimmune diseases: Ozone therapy may help reduce inflammation and improve immune function in conditions such as multiple sclerosis, rheumatoid arthritis, and lupus.
- Skin conditions: Ozone therapy may help treat various skin conditions, including eczema, psoriasis, and acne, by improving blood circulation and oxygenation.
Moreover, ozone therapy is a safe and non-invasive treatment that doesn’t have the side effects commonly associated with traditional medical treatments. It’s also relatively inexpensive and can be administered in a variety of settings, including clinics, hospitals, and private practices.
What does the latest research say about ozone therapy?
Although the scientific evidence on the effectiveness and safety of ozone therapy remains limited, some recent studies have suggested that ozone therapy may have potential health benefits in certain conditions.
A study published in the Cuban journal of immunology describes the immunomodulatory properties of ozone therapy by characterizing the biological effects of ozone on immune system cells, soluble mediators and other cell types.
In another example, in a 2022 review on ozone therapy in pain medicine, authors agree on the high safety of pain treatments with ozone therapy, especially modern medical ozone generators with great precision. Similarly, a 2020 study on Systemic ozone therapy in insulin-dependent diabetic patients found that the analgesic and anti-inflammatory properties of ozone currently make it one of the most efficient therapeutic tools for the control of chronic pain in insulin-dependent diabetic patients.
Ultimately, ozone therapy is a promising alternative medical treatment that has been used to treat various medical conditions. Many people claim to have experienced significant health benefits from this alternative treatment. Furthermore, ozone therapy is a safe and non-invasive treatment that doesn’t have the side effects commonly associated with traditional medical treatments.
If you’re interested in ozone therapy, make sure to do your research, ask questions, and consider this alternative medical treatment as a potential option for your health concerns. It’s important to stay informed about the latest developments in stem cell therapy. You can learn more about regenerative medicine and stem cells by enrolling in our international certification program at www.issca.us
- Published in Blog
Personalized Regenerative Medicine: The Future of Regenerative Medicine
Regenerative medicine is a rapidly growing field that focuses on repairing or replacing damaged or diseased tissues and organs using stem cells, growth factors, and other advanced therapies. The effectiveness of this approach has been demonstrated in treating a wide range of conditions, including heart disease, diabetes, joint pain, and neurological disorders. One of the major challenges of regenerative medicine, however, is that not every patient responds to the same treatment. This is where personalized regenerative medicine comes into play.
What is Personalized Regenerative Medicine?
Personalized regenerative medicine involves tailoring treatments to meet the unique needs of each patient based on their genetic profile, lifestyle, and medical history. This approach recognizes that no two patients are the same, and that a one-size-fits-all approach to regenerative medicine is not always effective.
As part of personalized regenerative medicine, advanced technologies such as genomics, proteomics, and metabolomics are used to analyze a patient’s unique biological profile. In order to provide customized and targeted treatment to patients, regenerative medicine centers utilize this information to develop personalized treatment plans tailored to their individual needs and conditions, ranging from stem cell therapy to gene therapy.
Why is Personalized Regenerative Medicine the Future of Regenerative Medicine?
There are several reasons why personalized regenerative medicine is the future of regenerative medicine:
- More effective treatments: By tailoring treatments to individual patients, personalized regenerative medicine has the potential to be much more effective than traditional one-size-fits-all approaches.
- Improved patient outcomes: Because personalized regenerative medicine takes into account the unique needs and conditions of each patient, it has the potential to improve patient outcomes and reduce the risk of complications.
- Lower healthcare costs: By providing more effective treatments and reducing the risk of complications, personalized regenerative medicine has the potential to lower healthcare costs in the long run.
- Better understanding of disease: Personalized regenerative medicine involves analyzing a patient’s unique biological profile, which can help researchers and healthcare providers better understand the underlying mechanisms of disease.
- Advancements in technology: As technology continues to advance, personalized regenerative medicine will become even more precise and effective, leading to even better patient outcomes.
The concept of personalized regenerative medicine is an exciting new approach to regenerative medicine that has the potential to revolutionize the healthcare industry. Individualized regenerative medicine has the potential to be more effective, improve patient outcomes, lower healthcare costs, and provide better understanding of disease by tailoring treatments to the individual patient. As technology continues to advance, we can expect to see even more exciting developments in this field in the years to come.
You can learn more about regenerative medicine and stem cells by enrolling in our international certification program at www.issca.us
- Published in Blog
Revolutionizing Neurodegenerative Care: The Advancements in Stem Cell Therapy
Neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease and amyotrophic lateral sclerosis, are a group of incurable neurological disorders, characterized by the chronic progressive loss of different neuronal subtypes. The conditions are debilitating and affect millions of people worldwide. Despite its increasing prevalence among the ever-increasing aging population, little progress has been made in the coincident immense efforts towards development of therapeutic agents. However, recent advancements in stem cell therapy including stem cells-derived exosomes, neurotrophic factors (NTFs), and their combination as potential therapeutic agents in neurodegenerative diseases.
In recent years, stem cells have emerged as one of the most active research therapeutic tools for many diseases. Stem cells are undifferentiated cells that have the ability to develop into pluripotent stem cells and adult stem cells. All stem cells have the potentiality of continuous self-renewal, high proliferation, and multidirectional differentiation into various cell types to replace degenerated or dead cells. In the context of neurodegenerative diseases, stem cells can be used to replace lost or damaged neurons, provide neuroprotection, and promote neural repair. These properties make stem cells an attractive option for treating neurodegenerative diseases, as they have the potential to slow or even reverse the progression of these conditions.
One of the key benefits of stem cell therapy for neurodegenerative diseases is that it offers a non-invasive, minimally-invasive, and non-toxic alternative to traditional treatments. Unlike drugs and surgery, stem cell therapy does not produce adverse side effects, and can be administered in a safe and controlled manner. In clinical trials, stem cell therapy has been shown to be effective in reducing symptoms and improving quality of life for patients with neurodegenerative diseases.
- Alzheimer’s disease (AD)
Alzheimer’s disease (AD) is a progressive neurodegenerative disease and the most common form of dementia, affecting approximately 55 million people worldwide. Cognitive impairment is a hallmark of AD. Currently, drug therapies can only delay symptoms, but not relieve disease pathology or progression. Researchers have demonstrated that neurons derived from stem cells can integrate with existing neural networks and repair damaged neurons within the host brain, improving learning and memory deficits, and NTFs can improve AD symptoms and provide neuroprotective effects.
- Parkinson’s disease (PD)
The second most common neurodegenerative disorder is Parkinson’s disease (PD). The motor symptoms of PD mainly include rest tremor, rigidity, bradykinesia and postural instability, while common nonmotor symptoms include neuropsychiatric and sleep disorders as well as sensory and autonomic dysfunction. At present, there is no cure for PD or disease-modifying therapy. It is common for symptom-relief medications to only provide partial relief and elicit side effects such as motor complications, gastrointestinal problems, and neurological issues. In spite of the fact that these treatments do not address the underlying pathology, alternative therapies, especially those based on stem cells and NTFs, are still being pursued intensively.
- Huntington’s disease (HD)
Huntington’s disease (HD) is characterized by motor, cognitive, and psychiatric dysfunctions. The study of multiple possible neurodegenerative mechanisms of HD is currently underway, and this knowledge is expected to contribute to the development of new HD treatments. The abilities of stem cells to rescue or replace the damaged and dying neurons, and to prevent further cell damage and death, make stem cell-based therapies promising for treatment of this neurode-generative disease.
- Amyotrophic lateral sclerosis (ALS)
As a neurodegenerative disorder, amyotrophic lateral sclerosis (ALS) involves progressive degeneration of both upper and lower motor neurons, resulting in palsy and death within 3-5 years of onset. Currently, only two disease-modifying medicines are available, each showing benefit to a limited number of patients. Stem cell-based therapy holds great promise for treating ALS by providing both cell replacement and NTF delivery to target the multiple pathologies. Stem cells available for ALS treatment include NSCs, MSCs, embryonic stem cells, induced pluripotent stem cells, and olfactory ensheathing stem cells.
While stem cell therapy is still in the early stages of development, it holds enormous promise as a future treatment for neurodegenerative diseases. A number of studies have demonstrated that stem cells and NTFs offer considerable therapeutic potential, especially when they are used together. In addition to replenishing target neurons, stem cells combined with NTFs can produce neurotrophins to improve the microenvironment that promotes nerve repair and regeneration. As research continues, we can expect to see even more exciting advancements in this field, bringing hope to those affected by these debilitating conditions.
It’s important to stay informed about the latest developments in stem cell therapy. You can learn more about regenerative medicine and stem cells by enrolling in our international certification program at www.issca.us
- Published in Blog
Mesenchymal Stem Cells For Cardiovascular Diseases
Despite progress in cardiovascular research, cardiac pathology continues to be one of the most common causes of morbidity and mortality in the world. Stem cell-based therapy has been recognized as an innovative strategy for the repair, regeneration and functional recovery of the myocardium, hence, once the animal research stage has been overcome, most clinical trials aimed at evaluating the safety and effectiveness of regenerative medicine in cardiovascular diseases have focused on angina pectoris, myocardial infarction and chronic cardiomyopathy. Although the current evidence of benefit is not conclusive, the evidence in favor of favorable results is growing.
In some cases, stem cell therapy can provide an effective treatment or alternative for diseases or disorders for which there is no effective treatment. Because these cells are capable of dividing into a wide range of lineages and tissues, they can be used to treat various diseases by repairing, replacing, and regenerating tissues.
It is unclear how umbilical cord mesenchymal stem cells act on the heart, but previous studies have shown that they possess an anti-apoptotic effect. The induced cardiomyocytes can form discs interspersed with myocytes from the host cells, creating a functional syncytium that will help contract the heart. Mesenchymal stem cells can improve cardiac function and reduce damage caused by cardiovascular disease, since they stimulate endogenous repair mechanisms, the regulation of the immune response, tissue perfusion and the proliferation of the resident heart rate, thereby improving cardiac function and reducing damage severity.
Refractory angina
This syndrome, characterized by persistent angina despite standard medical treatment, is often not revascularized due to diffuse coronary lesions or severe comorbidities.
In 2017, a review included 13 clinical studies, with 1061 patients and 12 months of follow-up on average, indicating cell therapy has emerged as a tool for managing these patients. Although the available data are inconclusive, the authors conclude that stem cell-based therapy could be a viable addition to conventional treatment options for refractory angina, given the paucity of therapeutic alternatives.
There was a reduction in mortality at two years after a meta-analysis in 2018, involving 304 patients, showed improved exercise tolerance and reduced angina attack frequency at three, six and 12 months. An additional meta-analysis published in March 2019, involving 526 patients monitored for 14 months, showed that patients treated with stem cells had fewer serious adverse effects, fewer deaths, fewer angina attacks, and fewer antianginal medications than those treated with conventional management.
A third meta-analysis from 2019, with 269 patients and 15 months of follow-up on average, reports the following results: decreased all-cause mortality, decreased frequency of angina and increased exercise time, with no increase in adverse reactions.
Cardiomyopathy (ischemic and non-ischemic)
Despite optimal medical and surgical management, many patients with heart failure undergo long-term myocardial remodeling that does not allow them to restore their ventricular function. This is because current treatment protocols cannot reverse the loss of cardiomyocytes due to cardiomyopathy. Since inflammatory responses continue over time as a central mechanism in the development of heart failure, it was of interest to investigate the anti-inflammatory, antifibrotic, and immunomodulatory properties of stem cells in patients with ischemic and non-ischemic cardiomyopathy.
In a review of five clinical studies published between 2017 and 2018, including 605 patients, the authors conclude that cell therapy is safe, causes immunomodulatory effects, improves functional capacity, and adds clinical benefits to standard therapies. According to them, the results are promising, and further evidence strengthening is recommended.
Based on a meta-analysis published in May 2019, involving 20 investigations and 1418 patients evaluated for an average of 21 months, stem cells improved cardiac function indicators (LVEF and LVESV), walking distance, functional classification of heart failure, quality of life, and mortality as compared to controls. Hospitalizations and serious adverse events were not different from those in the control group.
In a recent review of 9 studies involving 612 patients with heart failure, improvement was found in clinical and paraclinical parameters, evaluated on average for 9 months. According to the authors, stem cells are an effective therapy for the treatment of heart failure, improving patient prognosis and ability to exercise.
Acute myocardial infarction (AMI)
The application of stem cells was associated with a significant increase in left ventricular ejection fraction (LVEF) and other variables indicative of improved ventricular function and modification of remodeling in patients with AMI receiving timely percutaneous coronary intervention (PCI) and conventional medication in different studies. Even coronary artery bypass grafting with stem cells offers greater benefits. A number of studies have also shown that intravenous administration could be a more efficient and effective method of treating the heart or coronary arteries than direct application, with logistic, safety, and cost advantages.
Stem cell therapy is evidenced to be a safe way to treat cardiovascular diseases, as it shows an anti-apoptotic effect, reduction of lesion size, improvement of cardiac function through regulation of the immune response, adequate tissue perfusion and activation of growth factors.
We still need to explore a lot of ground, in terms of these and other conditions. You can learn more about regenerative medicine and stem cells by enrolling in our international certification program at www.issca.us
- Published in Blog
Atherosclerosis obliterans grade IV: Application of Autologous Stem Cells
Atherosclerosis is the most common form of arterial occlusive disease in adults. About 15 percent of adults over 55 years of age suffer from critical ischemia, the most severe form of this disease.
Due to the gradual aging of the population and the growing number of people in their third age group, a number of studies have been conducted in order to improve the prognosis of atherosclerosis obliterans and to find alternatives to the mutilation of the extremities. As a general rule, chronic ischemia of the lower limbs should be treated to alleviate symptoms, particularly pain, prevent disease progression, and reduce the rate of amputations. In most patients with critical ischemia, the main goal is to preserve the affected limb.
The development of regenerative medicine is closely linked to the development of new knowledge about embryonic and adult stem cells, as well as the regenerative and therapeutic potential of stem cell therapy. The use of adult stem cells in the treatment of peripheral artery diseases has been demonstrated as a therapeutic agent for inducing angiogenesis. Recent preclinical studies as well as the pioneering clinical studies indicate that bone marrow-derived mononuclear cells (MBMCs) can enhance tissue vascularization in ischemic limbs, with results similar to those obtained with peripheral blood stem cells supply.
Cuba presented the first studies carried out in 2004 at the Institute of Hematology of the “Enrique Cabrera” hospital in Havana City, which achieved encouraging clinical results and had very few adverse effects in recent years.
A progressive rise in the accumulated experience with stem cells was also observed in Pinar del Rio in 2005, as the first 10 cases were carried out. The rising ease of obtaining this type of cell has made research and applications with these cells advance rapidly with great expectations in terms of clinical application.
A study published by Dia-Diaz, et al. in the Journal of Medical Sciences of Pinar del Rio examined 296 patients with grade IV atherosclerosis obliterans between 2009 and 2019. During the study, autologous stem cells were injected intramuscularly from peripheral blood. Within four weeks, pain relief was observed, as well as an increase in the pain-free claudication distance. Angiography after treatment revealed collateral vessel formation. The limb was saved in 201 patients (68%), while 95 cases (32%) presented amputation criteria. Complications were not reported following the procedure.
The study demonstrated the effectiveness of the implantation of autologous stem cells obtained from peripheral blood, as well as the favorable evolution of patients, clinical improvement of rest pain, walking distance without claudication and ankle-brachial pressure index.
We still need to explore a lot of ground, in terms of these and other conditions. You can learn more about regenerative medicine and stem cells by enrolling in our international certification program at www.issca.us
- Published in Blog
The emerging role of MSC-derived exosomes in Regenerative Medicine
In recent years, MSCs have been introduced as respectable candidates for regenerative medicine due to their pro-angiogenic, anti-apoptotic, and immunomodulatory attributes. A variety of human tissues can be used as a source of mesenchymal stem/stromal cells (MSCs), ranging from bone marrow (BM) to umbilical cord (UC). These cells are typically multipotent and can differentiate into a variety of cell types. MSCs have been studied extensively for potential applications in cardiomyopathy, neurodegenerative disorders, spinal cord injuries (SCI), kidney injuries, liver injuries, lung injuries, and even cancer. According to current research, MSC-derived extracellular vesicles (EVs) contribute to MSC-exerted therapeutic benefits.
As defined by the International Society for Extracellular Vesicles (ISEV), EVs are lipid bilayer particles secreted by cells that do not replicate. EVs can be categorised into three subclasses based on size and biogenesis procedures: surrounding exosomes (50-150 nm), microvesicles (MVs) (100-1000 nm), and apoptotic bodies (ApoBDs) (500-5000 nm). In order for exosomes to be produced, multiple steps must occur; endosomes must be created from the plasma membrane, intraluminal vesicles must be formed within multivesicular bodies by inward budding, the MVB must merge with the plasma membrane, and finally the internal vesicles must be released.
By transmitting their molecules, such as proteins, messenger RNA (mRNA), and microRNAs (miRNAs), MSC exosomes stimulate phenotypic changes and subsequently modify regenerative programs of target organs. A number of mechanisms are involved in phenotypic alterations, including prevention of apoptosis, cell proliferation, immunomodulatory reactions, attenuation of oxidative stress, and improving oxygen supply to recipient cells. By supporting mitochondrial transfer, MSC-exosomes can suppress inflammatory cytokine production and induce phenotype 2 alveolar macrophages (M2), leading to acute lung injury (ALI) rescue. It has been demonstrated that the transmission of miRNAs from MSC-exosomes to recipient cells is responsible for the restoration of damaged kidneys, hearts, livers, and brains
Various cells continuously form and secrete exosomes, including lymphocytes, platelets, mast cells, intestinal epithelium, dendritic cells, neoplastic cell lines, microglia, neurons, and MSCs. Studies have shown that exosomes play an important role in cell-to-cell communication as well as several physiological and pathological processes. Despite their inherent biological activities, exosomes have recently been introduced as encouraging drug carriers because of their small size, high biocompatibility, and ability to hold different therapeutic ingredients, including proteins, nucleic acids, and small molecules. There have been reports showing the usefulness of MSCs-exosomes for treating a variety of ailments, such as lung, kidney, liver, neurodegenerative, cardiac, and musculoskeletal diseases, as well as skin wounds in vivo.
As well as their remarkable therapeutic effects, MSC-EVs derived from diverse sources also possess a variety of physiological functions that may affect their therapeutic application. In a wide range of human disorders, MSC-exosomes are considered an effective alternative to whole-cell therapy because of their low immunogenicity and improved safety profile. Although MSC-exosome applications still face various challenges, their benefits and capabilities are attracting increasing interest.
To learn more about stem cells, exosomes and keep up to date with all the information about regenerative medicine and its advances, sign up for our international certification in regenerative medicine at www.issca.us
- Published in Blog